A-1210477
MedKoo试剂A-1210477(CAS#:1668553-26-1)
产品品牌：MedKoo
产品货号：407156
产品规格：10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g;
产品价格：咨询
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产品介绍
产品简介：
A -1210477是一种有效的选择性MCL-1抑制剂。A-1210477诱导内在凋亡的标志，并证明单药杀死多发性骨髓瘤和非小细胞肺癌细胞系。a -1210477与BCL-2/BCL-XL抑制剂navitoclax协同杀死多种癌细胞系。a -1210477是一种潜在的治疗癌症的药物。抗凋亡蛋白MCL-1是癌细胞存活的关键调节因子，也是小分子BCL-2家族抑制剂(如ABT-263 (navitoclax))的已知耐药因子，使其成为一个有吸引力的治疗靶点。
产品属性：
Chemical Formula: C46H55N7O7S
Exact Mass: 849.38837
Molecular Weight: 850.05
Elemental Analysis: C, 65.00; H, 6.52; N, 11.53; O, 13.17; S, 3.77
Synonym: A-1210477; A 1210477; A1210477.
IUPAC/Chemical Name: 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
InChi Key: XMVAWGSQPHFXKU-UHFFFAOYSA-N
InChi Code: InChI=1S/C46H55N7O7S/c1-33-43(41(49(4)47-33)32-60-36-19-17-35(18-20-36)51-22-24-52(25-23-51)61(56,57)48(2)3)40-14-8-13-38-39(15-9-29-59-42-16-7-11-34-10-5-6-12-37(34)42)45(46(54)55)53(44(38)40)26-21-50-27-30-58-31-28-50/h5-8,10-14,16-20H,9,15,21-32H2,1-4H3,(H,54,55)
SMILES Code: O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C(C=CC=C4)C4=CC=C3)C5=C1C
(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
产品订购：
货号 | 产品名称 | 规格 |
407156 |
A-1210477 | 10.0mg 25.0mg 50.0mg 100.0mg 200.0mg 500.0mg 1.0g 2.0g |
