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产品介绍
产品简介：
Dovitinib，也被称为TKI-258或CHIR-258，是一种口服生物可利用的FGFR3抑制剂，与成纤维细胞生长因子受体3 (FGFR3)强烈结合并抑制其磷酸化，从而可能导致抑制肿瘤细胞增殖和诱导肿瘤细胞死亡。此外，这种药物可能抑制RTK超家族的其他成员，包括血管内皮生长因子受体;成纤维细胞生长因子受体1;血小板衍生生长因子受体3型;fms样酪氨酸激酶3;干细胞因子受体(c-KIT);集落刺激因子受体1;这可能导致细胞增殖和血管生成的额外减少，并诱导肿瘤细胞凋亡。
产品属性：
Chemical Formula: C21H21FN6O
Exact Mass: 392.1761
Molecular Weight: 392.4384
Elemental Analysis: C, 64.27; H, 5.39; F, 4.84; N, 21.42; O, 4.08
Synonym: TKI258; TKI-258; TKI 258; CHIR258; CHIR-258; CHIR 258; Dovitinib lactate
IUPAC/Chemical Name: 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinon
InChi Key: PIQCTGMSNWUMAF-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
SMILES Code: O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
产品订购：
货号 | 产品名称 | 规格 |
206984 |
Dovitinib free base | 50.0mg 100.0mg 200.0mg 500.0mg 1.0g 2.0g 5.0g |
