4'-O-Methylhonokiol(CAS#:68592-15-4)
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产品介绍
Description: 4'-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities. It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis and the fungus T. mentagrophytes. 4'-O-Methylhonokiol inhibits LPS-induced activation of NF-kB and production of nitric oxide in RAW 264.7 macrophages. In vivo, 4'-O-Methylhonokiol reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer's disease induced by amyloid-β 1-42 when administered at a dose of 1 mg/kg.3 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.
Name: 4'-O-Methylhonokiol
CAS#: 68592-15-4
Chemical Formula: C19H20O2
Exact Mass: 280.1463
Molecular Weight: 280.367
Elemental Analysis: C, 81.40; H, 7.19; O, 11.41
Synonym: 4-Methoxyhonokiol; NSC 293101; NSC293101; NSC-293101;
IUPAC/Chemical Name: 3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-ol
InChi Key: OQFHJKZVOALSPV-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
SMILES Code: C=CCC1=CC(C2=CC(CC=C)=C(C=C2)OC)=C(C=C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
