2-OHE1(CAS#:362-06-1)
热线电话: 400-888-3135
热线电话: 400-888-3135
产品介绍
Description: 2-hydroxy Estrone (2-OHE1) is an active metabolite of the endogenous estrogen estrone. It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1A2, CYP1A1, and CYP1B1 and metabolized to 2-methoxy estrone by catechol-O-methyltransferase (COMT). 2-hydroxy Estrone (10 µM) inhibits the proliferation of estrogen receptor-positive MCF-7, but not estrogen receptor-negative MDA-MB-231, breast cancer cells cultured with the COMT inhibitor quinalizarin. It inhibits iron-ADP-adriamycin complex-induced lipid peroxidation of liposomes prepared from rat liver microsomes (IC50 = 2.7 µM).
Name: 2-OHE1
CAS#: 362-06-1
Chemical Formula: C18H22O3
Exact Mass: 286.1569
Molecular Weight: 286.371
Elemental Analysis: C, 75.50; H, 7.74; O, 16.76
Synonym: 2-OHE1; 2OHE1; 2 OHE1; 2-hydroxy Estrone; 2 hydroxy Estrone; Catecholestrone; 2-hydroxy E1; 2 hydroxy E1;
IUPAC/Chemical Name: (8R,9S,13S,14S)-2,3-dihydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one
InChi Key: SWINWPBPEKHUOD-JPVZDGGYSA-N
InChi Code: InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1
SMILES Code: C[C@]12[C@]([H])([C@]3([C@@]([H])(C4=CC(O)=C(C=C4CC3)O)CC2)[H])CCC1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
