Description: 12-Epinapelline is a diterpenoid alkaloid that has been found in Aconitum and has antiarrhythmic activity. It has antiarrhythmic activity in a rat model of aconitine-induced arrhythmia and antifibrillatory activity in a mouse model of aconitine-induced cardiac fibrillation (ED50s = 8 and 20 mg/kg, respectively).

Name: 12-Epinapelline

Chemical Formula: C₂₂H₃₃NO₃
Exact Mass: 359.246
Molecular Weight: 359.51
Elemental Analysis: C, 73.50; H, 9.25; N, 3.90; O, 13.35

Synonym: 12 epi Napelline; 12epi Napelline; 12-epi Napelline; 12-Epinapelline; 12Epinapelline; 12 Epinapelline

IUPAC/Chemical Name: (3R,6S,6aS,6bR,8R,9R,11R,11aR,12R,12aR,14R)-1-ethyl-3-methyl-10-methylenetetradecahydro-3,6a,12-(epiethane[1,1,2]triyl)-9,11a-methanoazuleno[2,1-b]azocine-6,8,11-triol

InChi Key: AZAZKLKDEOMJBJ-PQNIRSBSSA-N

InChi Code: InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3/t12-,13+,14-,15-,16-,17+,18-,19-,20+,21+,22-/m1/s1

SMILES Code: O[C@@H]1[C@@]23[C@]4([C@@]5([C@@H]6[C@]2(N(CC)C[C@@](CC1)(C)[C@H]3C6)[H])C[C@@H]([C@H](O)C4)C([C@H]5O)=C)[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001