3PO(CAS#:18550-98-6)
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产品介绍
Description: 3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer. Note: this product has been assigned 2 CAS#: 18550-98-6 and 13309-08-5,
Name: 3PO
CAS#: 18550-98-6
Chemical Formula: C13H10N2O
Exact Mass: 210.0793
Molecular Weight: 210.236
Elemental Analysis: C, 74.27; H, 4.79; N, 13.33; O, 7.61
Related CAS #: 18550-98-6 13309-08-5
Synonym: 3PO
IUPAC/Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
InChi Key: UOWGYMNWMDNSTL-ONEGZZNKSA-N
InChi Code: InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
SMILES Code: O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
