Domiphen Bromide(CAS#:538-71-6 (Br))
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产品介绍
Description: Domiphen bromide is a quaternary antiseptic used as an antifungal agent. Domiphen bromide has potent activity on blockade of human ether-a-go-go related gene (HERG) channels. Domiphen bromide inhibited HERG channel currents in a dose-dependent manner with IC50 values of 9nM. Block of HERG channel by domiphen bromide was voltage-dependent and use-dependent. Domiphen bromide caused substantial negative shift of the activation curves, accelerated activated process, but had no effects on the deactivation and reactivation processes.
Name: Domiphen Bromide
CAS#: 538-71-6 (Br)
Chemical Formula: C22H40BrNO
Exact Mass:
Molecular Weight: 414.472
Elemental Analysis: C, 63.75; H, 9.73; Br, 19.28; N, 3.38; O, 3.86
Synonym: Domiphen, Domiphen Br, Domiphen bromide, Bradasol, Fungitex, Oradol
IUPAC/Chemical Name: N,N-dimethyl-N-(2-phenoxyethyl)dodecan-1-aminium bromide
InChi Key: OJIYIVCMRYCWSE-UHFFFAOYSA-M
InChi Code: InChI=1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1
SMILES Code: CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1.[Br-]
Appearance: White to off-white crystalline powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
