Description: 11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.

Name: 11-Dehydrocorticosterone

Chemical Formula: C₂₁H₂₈O₄

Exact Mass: 344.1988

Molecular Weight:344.451

Elemental Analysis:C, 73.23; H, 8.19; O, 18.58

Synonym: 11-Dehydrocorticosterone; 11 Dehydrocorticosterone; 11-DHC; 11 DHC; DHCS; Kendall's Compound A; Kendall's Compound-A; NSC 9702; NSC9702; NSC-9702;

IUPAC/Chemical Name: (8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-3,11(2H)-dione

InChi Key: FUFLCEKSBBHCMO-KJQYFISQSA-N

InChi Code: InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1

SMILES Code: C[C@@]12[C@@]3([C@]([H])([C@]4([C@]([C@@H](C(CO)=O)CC4)(C)CC3=O)[H])CCC1=CC(CC2)=O)[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001