Docebenone(CAS#:80809-81-0)
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产品介绍
Description: Docebenone is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 0.8 µM). It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). Docebenone inhibits the production of 5-HETE and leukotriene B4 (LTB4) induced by A23187 with IC50 values of 0.03 and 0.08 µM, respectively, in isolated rat peritoneal macrophages. It reduces paw edema, pleurisy, and cell infiltration induced by carrageenan in rats when administered at a dose of 80 mg/kg. Docebenone (20 mg/kg) reduces ovalbumin-induced bronchoconstriction in an ovalbumin-sensitized guinea pig model of experimental allergic asthma.
Name: Docebenone
CAS#: 80809-81-0
Chemical Formula: C21H26O3
Exact Mass: 326.1882
Molecular Weight: 326.44
Elemental Analysis: C, 77.27; H, 8.03; O, 14.70
Synonym: Docebenone; A61589; A-61589; A 61589; AA 861; AA-861; AA861;
IUPAC/Chemical Name: 2,5-Cyclohexadiene-1,4-dione, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-
InChi Key: WDEABJKSGGRCQA-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h22H,5,7-10,12,14-15H2,1-3H3
SMILES Code: O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
